8 / COMPOSITIONS AND METHODS FOR INCREASING MUSCLE MASS AND MUSCLE STRENGTH BY SPECIFICALLY ANTAGONIZING GDF8 AND/OR ACTIVIN A

摘要

The present invention provides compositions and methods comprising specifically antagonizing GDF8 and Activin A. In certain embodiments, a composition is provided comprising a GDF8-specific binding protein and an activin A-specific binding protein. For example, the present invention includes a composition comprising an anti-GDF8 antibody and an anti-activin A antibody. In another embodiment, an antigen-binding molecule is provided comprising a GDF8-specific binding domain and an activin A-specific binding domain. For example, the present invention includes bispecific antibodies that bind GDF8 and Activin A. The compositions of the present invention are useful for treating diseases and conditions characterized by reduced muscle mass or muscle strength, and other conditions treatable by antagonizing GDF8 and / or activin A activity.