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WNT Indazole Inhibitors of The WNT Signal Pathway and Therapeutic Uses Thereof

机译:WNT信号通路的WNT吲唑抑制剂及其治疗用途

摘要

Indazole compounds for the treatment of various diseases or etiologies are disclosed. More specifically, the present invention mediates by treatment of disorders characterized by activation of Wnt pathway signaling (eg cancer, abnormal cell proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), Wnt pathway signaling Indazole compounds in genetic diseases and neurological conditions / disorders / diseases caused by the regulation of cell events, as well as by mutation or dysregulation of the Wnt pathway and / or mutation or dysregulation of one or more Wnt signaling components It relates to the use of analogues thereof. Also provided are methods of treating a Wnt-related disease state.
机译:公开了用于治疗各种疾病或病因的吲唑化合物。更具体地说,本发明通过治疗以Wnt途径信号转导为特征的疾病(例如,癌症,异常细胞增殖,血管生成,阿尔茨海默氏病,肺病和骨关节炎),遗传疾病和神经病学/疾病中Wind途径信号吲哚化合物为媒介由细胞事件的调节,以及由Wnt途径的突变或失调和/或一种或多种Wnt信号传导组分的突变或失调引起的/疾病,涉及其类似物的用途。还提供了治疗Wnt相关疾病状态的方法。

著录项

  • 公开/公告号KR102048107B1

    专利类型

  • 公开/公告日2019-11-22

    原文格式PDF

  • 申请/专利权人

    申请/专利号KR20147028706

  • 申请日2013-03-13

  • 分类号C07D513/02;A61K31/44;C07D515/02;

  • 国家 KR

  • 入库时间 2022-08-21 11:08:28

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