NK-3 N--5678---12443-a NK-3 NOVEL CHIRAL N-ACYL-5678-SUBSTITUTED-TETRAHYDRO-124TRIAZOLO43-aPYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS PHARMACEUTICAL COMPOSITION METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF

摘要

The present invention relates to compounds of formula (I) and their therapeutic use. The present invention also provides a novel chiral synthesis of 5,6,7, (8-substituted) -tetrahydro- [1,2,4] triazolo [4,3-a] pyrazine using an N-sp3 protecting group. It is about. The present invention also provides intermediates for use in the synthesis of compounds of formula (I).