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Mesenchymal stem cell culture media for preventing or treating immune disease or inflammatory disease and a method for preparing the same

机译:用于预防或治疗免疫疾病或炎性疾病的间充质干细胞培养基及其制备方法

摘要

The present invention relates to mesenchymal stem cell culture media for preventing or treating immune diseases or inflammatory diseases, and a method for preparing the same. The stem cell culture media, obtained by culturing mesenchymal stem cells in a three-dimensional culture by using a biocompatible scaffold in a serum-free medium, secretes a higher concentration of PGE2 as an immunoregulatory factor than the same of stem cell culture media obtained by a two-dimensional culture according to a conventional method, and has an excellent inhibition effect against an immune response and an inflammatory cytokine secretion. Thus, the stem cell culture media can be usefully used as a composition for preventing or treating immune diseases or inflammatory diseases.
机译:本发明涉及用于预防或治疗免疫疾病或炎性疾病的间充质干细胞培养基及其制备方法。通过在无血清培养基中使用生物相容性支架在三维培养物中培养间充质干细胞而获得的干细胞培养基分泌的PGE2作为免疫调节因子的浓度要高于通过相同方法获得的干细胞培养基。根据常规方法进行二维培养,对免疫应答和炎性细胞因子分泌具有优异的抑制作用。因此,干细胞培养基可以有效地用作预防或治疗免疫疾病或炎性疾病的组合物。

著录项

  • 公开/公告号KR20200000415A

    专利类型

  • 公开/公告日2020-01-02

    原文格式PDF

  • 申请/专利权人 ANTEROGEN CO. LTD.;

    申请/专利号KR20190173945

  • 发明设计人 LEE SUNG KOO;KIM MI HYUNG;

    申请日2019-12-24

  • 分类号C12N5/0775;A61K31/5575;A61K35/28;C12N5;

  • 国家 KR

  • 入库时间 2022-08-21 11:08:11

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