Novel Multitarget Drugs for Treating Diseases in Mammals

摘要

The invention relates to chemistry, pharmacology and medicine of organic compounds, obesity, psoriasis by using benzyl (2S) -2- [2- (4-hydroxyphenyl) acetamido] -3-phenylpropanoate compounds , Crohn's disease, colitis, irritable bowel syndrome, diarrhea, nausea and vomiting, as well as cathepsin S, cannabinoid receptor type 1, takininine receptor types 1 and 2, prokineticin receptor types 1 and 2, bradykinin receptor type 1, relates to therapies for many other diseases associated with the activity of the melanocortin receptor MC4R, serotonin receptor 5-HT2B and NB-kB signaling pathway. Compounds and their pharmaceutically acceptable adducts, hydrates and solvates include cathepsin S inhibitors, cannabinoid receptor type 1 agonists, takininine receptor type 1 and 2 antagonists, prokineticin receptor type 1 and 2 antagonists Substances, bradykinin receptor type 1 antagonists, melanocortin receptor MC4R antagonists, serotonin receptor 5-HT2B antagonists, and NB-kB signaling pathway inhibitors. The invention also relates to a pharmaceutical composition comprising a therapeutically effective amount of a compound according to the invention.