DRUG COMBINATIONS FOR TARGETING MULTIPLE MUTATIONS IN CANCER to target multiple mutations in cancer

摘要

Methods of treating cancer in a patient are disclosed. The method comprises: (a) defining a set of agents targeting the identified pathogenic genes by screening cancer cell samples from patients by NGS or other techniques; (b) identifying two or more target genes, each containing a treatable mutation in the cancer cell; (c) testing the efficacy of one or more substances (sequentially or simultaneously administered) targeting a treatable mutation for each of the two or more identified target genes using an in vitro cultured cell experiment; And (d) specifying potential and effective therapeutic options to be used to treat the patient's cancer.