Methods and compositions for generating basal forebrain cholinergic neurons (BFCN)

摘要

The present invention provides methods and compositions for generating BFCN with repaired electrophysiological defects related to one or more mutations in basal progenitor cholinergic neurons (BFCN), particularly PSEN2, and cells for treating Alzheimer''s disease from stem cells- It relates to the use of such BFCN in base therapy.