The present specification relates to a composition for preventing or treating vemurafenib-resistant melanoma containing an inhibitor of the expression of LINC00518 as an active component. The inhibitor of the expression of LINC00518 is an oligonucleotide that binds to at least a part of the gene of LINC00518, and specifically can be any one or more of siRNA, shRNA, and miRNA. In addition, the present specification provides a method for screening a substance for preventing and treating vemurafenib-resistant melanoma with respect to a test substance.
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