STEM CELL-DERIVED MICROVESICLE WITH ENHANCED EFFICACY, USE THEREOF AND METHOD FOR STRENGTHENING EFFICACY THEREOF

摘要

The present invention relates to a stem cell-derived microvesicle with enhanced efficacy, a use thereof, and a method for strengthening efficacy thereof, and more particularly to a use of a stem cell-derived microvesicle with an enhanced expression level of microRNAs for preventing or treating stroke and a method for promoting a production and reinforcing an efficacy of the microRNAs in the stem cell-derived microvesicle, wherein the method is performed by subjecting stem cells to three-dimensional culture or ischemic stimulus to promote the production of stem cell-derived microvesicles and microRNAs in the microvesicles and also reinforce the efficacy of the stem cells and the microvesicles thereof. According to the present invention, the method has an excellent effect of not only promoting the production of the stem cell-derived microvesicle and microRNAs in the microvesicle, but also reinforcing the efficacy of the stem cells or microvesicles isolated therefrom. Accordingly, it is possible to obtain the stem cell-derived microvesicles containing a high level of substances including therapeutic microRNAs in large quantities and thus it is expected that the microvesicle will be useful in related fields of study and future clinical studies.;COPYRIGHT KIPO 2020