Industrial method of mono-alkylating piperidine nitrogen in piperidine derivatives using deuterated-alkyl

摘要

The present invention is a method for mono-alkylating piperidine nitrogen in a piperidine derivative using deuterated lower-alkyl, protecting piperidine nitrogen with an aralkyl protecting group, and deuteration-low- under neutral or basic conditions. It relates to a method comprising lower-alkylating a piperidine nitrogen using an alkylating agent and then deprotecting the aralkyl protecting group.