GPATCH4 Cell penetrating Domain derived from human GPATCH4 protein

摘要

The present invention relates to a cell membrane permeation domain derived from human GPATCH4 protein, and more particularly to a cell membrane permeation domain derived from human GPATCH4 protein (GPATCH4P1 cell membrane permeation domain) or cell permeation peptide and an intracellular delivery system comprising the same. The cell membrane permeation domain derived from the human GPATCH4 protein of the present invention and the same can be used to deliver cargo materials such as compounds, biomolecules, and various polymer materials into cells. The GPATCH4P1 cell membrane permeation domain of the present invention exhibits higher cell permeation efficiency compared to conventional cell permeation peptides, and is derived from human proteins, thereby avoiding side effects and immune responses caused by peptides derived from foreign proteins. It can be effectively used as a method for effectively delivering molecules and various polymer materials into cells.