Combination of local and systemic therapy to improve the treatment of skin conditions

摘要

The use of topical administration of halogenated xanthenes, such as Rose Bengal, in combination with the administration of one or more complementary targeted systemic skin therapies, preferably inflammatory pathways and in combination with administration of a therapy other than COX-1 and/or COX-2 inhibitor NSAID. Treatment is disclosed. Examples of complementary targeted systemic therapeutic components include corticosteroids including betamethasone dipropionate and fluorinonide; Ditranol; Vitamin D analogs, including calcipotriol; And retinoids; Non-biopharmaceuticals including methotrexate, cyclosporine, hydroxycarbamide, and fumarate with dimethyl fumarate; And one or more biopharmaceuticals comprising an antibody against TNF-α or a paratope-containing antibody portion, an anti-inflammatory cytokine interleukin-12, interleukin-23 and interleukin-17, and a TNF inhibitor. . Treatment of other epithelial tissues, such as the lining of the intestine, is also disclosed.