Nanoparticles containing synthetic variants of GM3 gangliosides as vaccine adjuvants

摘要

The present invention relates to methods of making nano-particulated adjuvants formed by synthetic variants of various GM3 gangliosides. Depending on the microstructure of fatty acids in the ceramide of synthetic GM3, the adjuvant can specifically stimulate a humoral or cellular immune response to the antigen in a specialized way. In particular, the present invention provides peptides, polypeptides or proteins formed through hydrophobic protein dispersion of the outer membrane complex (OMC) of Neisseria meningitidis in a solution containing a fully synthetic variant of GM3 ganglioside, and the aforementioned nanoparticles. It provides an immunogenic vaccine composition comprising.