Biomarker composition for early diagnosis of liver cancer

摘要

The present invention relates to a biomarker composition for early diagnosis of liver cancer. In the present invention, it was confirmed that the methylation of the exon site of the SPINK1 gene decreases and the expression of the SPINK1 gene and protein increases according to the progress of liver cancer. It is intended to be used as a biomarker for distinguishing liver cancer, and the SPINK1 has high accuracy and sensitivity, and thus can be usefully used as a biomarker composition for early diagnosis of liver cancer, a composition for early diagnosis of liver cancer, and a composition for predicting prognosis for early treatment of liver cancer.