PR-35 PR-35 antimicrobial peptide derived from natural variant of porcine gene and pharmaceutical composition comprising the same

摘要

The present invention provides an antimicrobial peptide consisting of the amino acid sequence of SEQ ID NO: 10, a method for discovering the same, and an antimicrobial pharmaceutical composition comprising the same, a food preservative, a feed additive, and a cosmetic additive. The PR-35 antimicrobial peptide derived from the natural variant of the pig gene of the present invention and a pharmaceutical composition comprising the same have lower cytotoxicity than the conventional PR-39 peptide and have excellent antibacterial activity against Gram-negative bacteria for multi-drug resistance in the medical and pharmaceutical fields. It can be useful as an alternative antibiotic.