Reversible gel for Parenteral drug delivery comprising non-concentric multi-nanodomain vesicles and nanoliposome and Composition for drug delivery comprising the same

摘要

The present invention relates to a non-concentric multi-nanodomain vesicle including two or more liposomes in contact with and connected to each other, and an outer wall surrounding the two or more liposomes; And a nanoliposome, wherein the non-concentric multi-nanodomain vesicle consists of an organic phase containing a hydrophobic drug and an aqueous phase containing a hydrophilic drug and has a negative charge, and the nanoliposome has a positive charge, A reversible gel for parenteral drug delivery is provided. The reversible gel for parenteral drug delivery according to the present invention can increase the encapsulation efficiency of various hydrophobic and hydrophilic drugs, and can be easily injected using a single syringe, and has the property of forming a gel in the body after injection. The present invention overcomes the limitations of the vesicle or liposome-based drug delivery system, which was difficult to induce the sustained-release behavior by moving to the surrounding tissues, and can be used in surgical sites, and loaded with drugs that regulate the functions of cancer cells and various immune cells. When used in combination with an immune checkpoint inhibitor, the reversible gel for parenteral drug delivery according to the above can dramatically improve the efficiency of anticancer immunotherapy.