The present invention relates to a pharmaceutical composition or an anticancer adjuvant for preventing or treating colon cancer comprising streptonigrin and an anticancer agent. In addition, the present invention relates to a pharmaceutical composition or anticancer adjuvant for preventing or treating 5-FU-resistant colorectal cancer comprising streptonigrin. Therefore, the composition of the present invention contains streptonigrin and oxaliplatin or streptonigrin and 5-FU, so that the effect of inhibiting the growth of colon cancer cell lines is significantly increased compared to the case of treatment alone. Or it may be provided as a therapeutic composition. In addition, in the case of 5-FU-resistant colorectal cancer cell lines, anticancer activity appears even when streptonigrin is treated alone, but when streptonigrin and 5-FU are used in combination, synergy occurs and thus significantly increased anticancer activity can be exhibited. have.
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