CCL2 Composition for improving milk yield comprising C-C motif chemokine ligand 2CCL2 and Pharmaceutical composition for preventing or treating mastitis comprising the same

摘要

The present invention relates to a composition containing CCL2 (CC motif chemokine ligand 2) as an active ingredient, and more particularly, a composition for increasing the amount of acid produced containing CCL2 as an active ingredient, feed additive composition, mastitis containing CCL2 as an active ingredient It relates to a pharmaceutical composition and a food composition for prevention or treatment. The composition comprising CCL2 according to the present invention as an active ingredient is made from proteins produced in the body, so compared to chemical compounds, toxicity or side effects in the body can be minimized, and the expression of proteins in the PI3K/AKT and MAPK signaling pathways is activated. It has the effect of improving the proliferation of breast epithelial cells, reducing the expression of endoplasmic reticulum stress-inducing proteins, and alleviating the inflammatory response. Compositions for increasing milk production, feed additive compositions, pharmaceuticals and functionalities that can prevent and treat mastitis It can be usefully used in food-related fields.