FOR PRODUCING AND USING METHOD OF BRAIN MAP BASED ON NEUROTRANSMITTERS

摘要

In order to evaluate the efficacy of a drug that increases or decreases a specific neurotransmitter according to an embodiment, in a method for measuring a change in the concentration of the specific neurotransmitter in a specific region in the brain with reference to a brain map, Selecting a first region of the animal corresponding to a region marked with the highest concentration of the first neurotransmitter in the brain map as the target region for microdialysis; And injecting the drug into the animal and confirming a change in the concentration of the first neurotransmitter at the first site between before and after the injection of the drug; including, the brain map of the human brain Concentration distribution of 11 or more neurotransmitters including serotonin, dopamine, GABA, glutamate, and metabolites thereof obtained by performing mass spectrometry on samples obtained at multiple sites of 1 Concentration distribution-and 11 or more of the above ascites, including serotonin, dopamine, GABA, glutamate, and metabolites thereof obtained by performing mass spectrometry on samples obtained from multiple regions of the brain of monkeys. Of the neurotransmitter concentration distribution-hereinafter the second concentration distribution-and the obtained first concentration distribution and the obtained second concentration distribution of the plurality of regions of the human brain and the plurality of regions of the brain of the monkey A first correlation including at least 11 or more correlation data corresponding based on the similarity of the concentration distribution of individual neurotransmitters identified in, and obtained using the second concentration distribution, the first site, In the case where the amount of the first neurotransmitter is the largest in the second site in the first concentration distribution, the present invention relates to a method for evaluating drug efficacy, which is a site corresponding to the second site in the second concentration distribution.