TGF1 Method for Differentiation of Stem Cells to Mature Subtype-specific Cardiomyocytes Using TGF1

摘要

The present invention relates to a method for differentiating stem cells into cardiomyocytes, and more particularly, to a method for inducing different types of stem cells into ventricular or atrial cells by using TGFβ1 and promoting differentiation into mature cardiomyocytes. will be. According to the present invention, treatment with TGFβ1 in the step of differentiating stem cells into cardiomyocytes enhances the induction of differentiation into ventricular or atrial cells with increased functional maturity. Therefore, the obtained stem cell-derived mature cardiomyocytes are very useful for cell therapy for cardiovascular disease, disease modeling, and new drug toxicity evaluation.