Activin receptor type IIB variants and methods of use thereof

摘要

The present invention features a polypeptide comprising an extracellular ActRIIB variant. In some embodiments, the polypeptides of the invention comprise extracellular ActRIIB variants fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of use of the polypeptides for treating diseases or conditions involving muscle weakness and atrophy, bone damage, low red blood cell levels (such as anemia or blood loss), fibrosis and/or pulmonary hypertension. To do.