The present invention relates to a corn-based carbon quantum dot showing excellent fluorescence quenching for GABA, a neurotransmitter, using enzyme reactions and electron transfer phenomena, and a Gaba method using the same. The present invention has excellent sensitivity and reproducibility because the carbon quantum dot uses the enzyme reaction of GABA and the redox reaction of the coenzyme attached to the quantum dot. In addition, since the Gaba measurement method of the present invention uses corn-based carbon quantum dots, it has high solubility, chemical stability, non-toxicity, and excellent biocompatibility compared to conventional metal quantum dots. In addition, the corn-based carbon quantum dot manufacturing method of the present invention not only uses corn, which is an eco-friendly material, but also hardly uses organic solvents or reactants during the manufacturing process, so it is eco-friendly and economical. The corn-based carbon quantum dots of the present invention have a very high photoluminescence efficiency for gaba compared to neurotransmitters such as adrenaline and dopamine glutamate, and thus gaba detection with high selectivity is possible.
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