Use in diseases and disorders associated with modified monocytes/macrophages/dendritic cells and protein aggregates expressing chimeric antigen receptors

摘要

The present invention relates to compositions and methods for treating diseases and/or disorders associated with protein aggregates. By expressing the chimeric antigen receptor (CAR) in monocytes, macrophages or dendritic cells, the modified cells are recruited or applied to the tissue microenvironment, where the cells infiltrate the tissue and eliminate, reduce, inhibit or prevent protein aggregation, thereby providing strong immunity. Acts as an effector. Another aspect of the invention is a method for treating conditions such as neurodegenerative diseases/disorders, inflammatory diseases/disorders, cardiovascular diseases/disorders, fibrotic diseases/disorders and amyloidosis, and CAR modified monocytes, macrophages or dendritic cells. It includes a pharmaceutical composition comprising.