首页> 外国专利> Antibody for inducing brown adipocyte differentiation and composition for preventing or treating metabolic syndromes containing the same

Antibody for inducing brown adipocyte differentiation and composition for preventing or treating metabolic syndromes containing the same

机译:诱导褐色脂肪细胞分化的抗体和用于预防或治疗代谢综合征的组合物

摘要

The present invention relates to a brown adipocyte differentiation-inducing antibody and a composition for preventing or treating metabolic diseases comprising the same as an active ingredient.According to the present invention, a novel H3 antibody and an IYD substrate that is an IYD (iodotyrosine deiodinase) agonist are Induces differentiation into brown adipocytes in the bar, which generates heat and consumes energy, thereby exhibiting the effect of treating obesity. In addition, the use of an antibody having a low side effect and a long half-life in the body can compensate for the disadvantages of conventional therapeutic agents and improve the therapeutic effect. Accordingly, the IYD agonist having the above effects can be usefully used as a pharmaceutical composition for preventing or treating metabolic diseases.
机译:本发明涉及一种棕色脂肪细胞分化诱导抗体和用于预防或治疗代谢性疾病的组合物,其作为有效成分。根据本发明,新型H3抗体和作为IYD(碘酪氨酸脱碘酶)的IYD底物。 )激动剂是在棒中诱导分化为褐色脂肪细胞,产生热量并消耗能量,从而发挥治疗肥胖的作用。另外,使用在体内具有低副作用和长半衰期的抗体可以弥补常规治疗剂的缺点并改善治疗效果。因此,具有上述效果的IYD激动剂可以有效地用作预防或治疗代谢疾病的药物组合物。

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