Fusion polypeptides in which pigment epithelial-derived factor peptide and elastin based polypeptide are combined and phamaceutical compositions for inhibiting angiogenesis comprising thereof

摘要

The present invention relates to a fusion polypeptide in which a 34-mer peptide of an epithelial-derived factor (PEDF) and an elastin-based polypeptide (EBP) are bound and its use, and the fusion of the present invention Polypeptides exhibit thermal responsiveness and have improved angiogenesis inhibitory activity, a novel drug for the treatment of neovascularization-dependent diseases such as retinal, corneal and choroidal neovascularization, tumor growth, cancer metastasis, diabetic retinopathy and asthma. It is expected to be used as a delivery system.