3 Pharmaceutical composition for the prevention or treatment of afferent nerve diseases comprising Tentonin 3 and use thereof

摘要

The present invention relates to a pharmaceutical composition for the prevention or treatment of afferent disease comprising a protein of Tentonin 3 or a polynucleotide encoding the same as an active ingredient, specifically, a component of a mechanosensitive channel protein When inhibiting Tentonin 3 (TTN3), the protein of Tentonin 3 or by confirming that the mechanical sensory current is reduced, the activity of the near-myelinated nerves of the mouse is greatly reduced and the blood pressure and pulse of the mouse is greatly reduced. The polynucleotide encoding the same can be usefully used as a pharmaceutical composition for the prevention or treatment of afferent neurological disease and hypotension.