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UDP- UDP-GLUCURONOSYLTRANSFERASE SINGLE NUCLEOTIDE POLYMORPHISM MARKERS AND USE THEREOF

机译:UDP- UDP-葡糖醛酸转移酶单核苷酸多态性标记及其用途

摘要

The present invention provides a composition for predicting or diagnosing diseases and drug susceptibility associated with an in vivo glucuronidation reaction using a UDP-glucuronosyltransferase (UGT) polymorphic marker, and the disease and drug susceptibility using the same. A prediction and diagnostic method. Glucuronidation reaction-related diseases and drug susceptibility diagnostic method according to the present invention exhibits high accuracy, especially for Asians including Koreans, can be quickly and easily diagnosed, increasing the therapeutic efficiency of the disease and dangerous drugs with side effects This may help determine the dosage of.
机译:本发明提供了用于预测或诊断与使用UDP-葡糖醛酸糖基转移酶(UGT)多态性标记的体内葡萄糖醛酸化反应有关的疾病和药物敏感性的组合物,以及使用该组合物的疾病和药物敏感性。一种预测和诊断方法。根据本发明的与葡萄糖醛酸化反应有关的疾病和药物敏感性诊断方法显示出很高的准确性,特别是对于包括韩国人在内的亚洲人,可以快速而容易地进行诊断,从而提高了该疾病和危险药物的治疗效率并具有副作用。剂量。

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