xCT Pharmaceutical composition for treating xCT inhibitor- resistant cancer

摘要

The present invention relates to a composition for enhancing sensitivity to xCT inhibitors comprising an inhibitor or activity inhibitor of CISD2 protein as an active ingredient. The present invention also relates to a method of providing information on determining whether to administer an xCT inhibitor or a method of screening a substance for enhancing sensitivity of an xCT inhibitor. The composition of the present invention can be effectively used as an anticancer agent or anticancer adjuvant by effectively overcoming the resistance to pereptosis apoptosis caused by xCT inhibitors.