IL-1 I Chimeric IL-1 Receptor Type 1 Agonists and Antagonists

摘要

In particular, it is natural to use to modulate the signaling of cells in response to interleukin-1 receptor I (IL-1RI), to treat disorders, and to detect and bind to cellular receptors, as well as other substances. It is characterized by cytokine domains that are not generated. Exemplary cytokine domains may contain amino acid residues of at least two parental cytokine domains, eg, receptor binding feature, surface feature, β strands, and loops from at least two parental cytokine domains. .