-Blood-brain barrier W/O/W Drug Delivery Platform Using Blood-brain Barrier Opening W/O/W Type Triolein Emulsion

摘要

In the present invention, the oil droplets contain triolein, and a water-oil / water / external water (Water / Oil / Water; W / O / W) -type triolein emulsion having a droplet inside the oil droplet is effective. A composition for drug delivery to a tissue having a close junction comprising a component and a method for preparing the same, the triolein emulsion having a W / O / W type structure according to the present invention retains the BBB opening activity of triolein The water droplet is encapsulated in the oil droplet while showing, and it contains surfactants, so it is excellent in safety. It can also contain oil-soluble drugs in the oil droplet, so it can be used as a complex preparation, such as brain, testis, and retina. Drugs can be delivered more effectively to tissues with tight junctions.