Calmangafodipir a new chemical entity and other mixed metal complexes methods of preparation compositions and methods of treatment

摘要

Mixed metal complexes of compounds of formula I or salts thereof, wherein the mixed metal consists of Group III-XII transition metals and Group II metals: Equation I (Where X, R ¹ , R ² , R ³ and R ⁴ are as defined herein) is a single step crystallization from a solution of the Group III-XII transition metal, the Group II metal and the compound of Formula I ( by one-step crystallization). A method of treating a pathological condition of a patient, for example a pathological condition caused by the presence of oxygen-derived free radicals, consists in administering the mixed metal complex to the patient.