The present invention is an induced pluripotent stem cell-derived mesenchymal stem cells (iMSC), a culture thereof, or a pharmaceutical composition for the prevention or treatment of skin diseases comprising exosomes isolated from iMSC or iMSC culture as an active ingredient, skin diseases It relates to a cosmetic composition and a stem cell therapeutic agent for the prevention or improvement of. When using the composition of the present invention, it is possible to provide a composition for improving, preventing or treating skin diseases and a stem cell therapeutic agent having an improved immunomodulatory function than the existing mesenchymal stem cells.
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