RECOMBINANT PROTEIN PRODUCED FROM PSEUDOMONAS AERUGINOSA-DERIVED CHOLINESTERASE GENE, AND COMPOSITION INCLUDING RECOMBINANT PROTEIN AS ACTIVE INGREDIENT FOR PREVENTING AND TREATING ORGANOPHOSPHOROUS OR CARBAMATE-BASED NERVE AGENT TOXICOSIS OR NERVOUS SYSTEM DISEASES CAUSED BY CHOLINE EFFECT

摘要

The present invention relates to: a recombinant protein (SEQ ID NO: 1) produced from a cholinesterase gene (SEQ ID NO: 2) derived from Pseudomonas aeruginosa, wherein the recombinant protein is not inhibited by an organophosphorous or carbamate-based nerve agent and maintains an ACHE activity; and a composition including the recombinant protein as an active ingredient for preventing and treating organophosphorus or carbamate-based nerve agent toxicosis or nervous system diseases caused by a choline effect. The composition can be used as a pharmaceutical composition for preventing and treating nervous system diseases, a health functional food, and a health supplement food.;COPYRIGHT KIPO 2020