VEGF-Grab A conjugate of VEGF-Grab protein and a drug and use thereof

摘要

The present invention relates to a conjugate of a VEGF-Grab protein and a drug and uses thereof, specifically, a fusion protein and a drug conjugate to which a VEGFR1 domain 2, a VEGFR1 domain 3 and an antibody fragment are linked, a cancer- or angiogenesis-related disease comprising the conjugate It relates to a pharmaceutical composition for the prevention or treatment of and a method for preventing or treating cancer or angiogenesis-related diseases. The conjugate comprising the VEGF-Grab protein and drug of the present invention is a multi-paratope VEGF decoy receptor, and can be used as a multi-purpose platform for treating cancer or angiogenesis-related diseases.