The present invention relates to a composition for preventing or treating colitis comprising a complex herbal extract and sulfasalazine as an active ingredient, and more specifically, a mixed extract of dermis and siho; And it relates to a pharmaceutical composition for preventing or treating colitis comprising sulfasalazine (Sulfasalazine) or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition according to the present invention can effectively prevent, delay, ameliorate or treat colitis, particularly inflammatory bowel disease (IBD) or irritabel bowel syndrome (IBS), as well as high doses of sulfasalazine. (sulfasalazine) The risk of side effects caused by long-term administration is remarkably low, so it can be very useful in developing colitis prevention or treatment.
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