The present invention relates to a composition for inhibiting apoptosis due to endoplasmic reticulum stress containing the storage protein 1 of silkworm as an active ingredient, specifically, a storage protein isolated from silkworm hemolymph and having an amino acid sequence represented by SEQ ID NO: 1 It relates to a composition for inhibiting apoptosis caused by endoplasmic reticulum stress caused by release of Ca 2+ into the cytoplasm, comprising 1 (Storage Protein 1; SP1) as an active ingredient. Silkworm storage protein 1 (SP1) of the present invention inhibits the release of ER Ca 2+ into the cytoplasm, and inhibits apoptosis due to endoplasmic reticulum stress by inhibiting CHOP and GRP78 expression.
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机译：本发明涉及一种抑制内质网应激引起的凋亡的组合物，其包含家蚕的贮藏蛋白1作为活性成分，特别是从家蚕的血淋巴中分离出的贮藏蛋白，其氨基酸序列为SEQ ID NO：1。本发明涉及抑制由Ca 2+（Sup> 2 + 释放到细胞质中引起的内质网应激引起的细胞凋亡的组合物，该组合物包含1（存储蛋白1; SP1）作为活性成分。本发明的家蚕贮藏蛋白1（SP1）通过抑制CHOP和GRP78的表达，抑制ER Ca 2 + 向细胞质的释放，并抑制由于内质网应激引起的细胞凋亡。
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