COMPLEX CHROMOSOME ENGINEERING FOR PRODUCTION OF HUMAN ANTIBODIES IN TRANSGENIC ANIMALS

摘要

The present invention relates to large-scale production of human antibodies by highly productive transgenic animals of fully human IgG up to 10 g/L in serum with human IgG1 subclass dominance. The present invention also supports the feasibility of manipulating complex chromosomes for complex genetic studies in non-murine mammalian species.