2 --12415--5- HETEROBICYCLO-SUBSTITUTED-124TRIAZOLO15-CQUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES

摘要

Compounds of formula GI (represented by the structural formula), which are antagonists of the A2A receptor, are disclosed, wherein "RG3", "Rd1" to "Rd4", "n", "m", "p", "W", "X" , "Y", and "Z" are defined herein. Also disclosed herein is the use of a compound described herein as an antagonist of the A2a receptor in the potential treatment or prevention of neurological disorders and diseases in which the A2A receptor is involved. Pharmaceutical compositions comprising such compounds and the use of such pharmaceutical compositions are also disclosed herein. Formula GI