ANTIBODY CONJUGATES TO CD74, COMPOSITIONS CONTAINING AN ANTIBODY CONJUGATES TO CD74, AND METHODS FOR USING ANTIBODY ANTIBODIES TO CD74

摘要

Provided herein are antibody conjugates with binding specificity for CD74, wherein the antibody comprises a non-natural amino acid at a site selected from the group consisting of HC-F404, HC-K121, HC-Y180, HC-F241, HC-221, LC-T22, LC-S7, LC-N152, LC-K42, LC-E161, LC-D170, HC-S136, HC-525, HC-A40, HC-S119, HC-S190, HC-K222, HC-R19, HC-Y52, or HC-S70, according to the Kabat, Chothia, or EU numbering scheme, and compositions comprising the antibody conjugates, including pharmaceutical compositions, methods of producing the conjugates, and methods of using the conjugates and compositions for therapy.