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CONSTRUCTION OF AN OBLIGATORY VECTOR BASED ON ONCOLITIC SIMPLE HERPES VIRUSES (oHSV) AND CONSTRUCTION FOR CANCER THERAPY
CONSTRUCTION OF AN OBLIGATORY VECTOR BASED ON ONCOLITIC SIMPLE HERPES VIRUSES (oHSV) AND CONSTRUCTION FOR CANCER THERAPY
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机译:基于单纯疱疹病毒(oHSV)的强制矢量的构建和癌症治疗的构建
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摘要
An obligate oHSV vector comprising modified viral DNA genome is provided. A recombinant oHSV-1 construct comprising the obligate oHSV vector and a heterologous nucleic acid sequence encoding an immunostimulatory and/or immunotherapeutic agent is also provided. Compositions comprising the recombinant oHSV-1 construct can be used for treating cancers.
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