USE OF GOLD POLYACRYLATE AS A HUMAN MELANOMA CELL GROWTH INHIBITOR

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medical chemistry and oncology. Disclosed is the use of gold polyacrylate (polyacrylic acid polymer containing gold (III) ions) as a cytotoxic agent for chemotherapy of melanoma. It is suggested that gold polyacrylate will be in demand for treating melanoma and preventing development of its resistance to chemotherapeutic agents.;EFFECT: gold polyacrylate has high specific activity on human and mouse melanoma cells with significantly lower acute toxicity (that is a wide therapeutic index) as compared to Cisplatin – the chemically closest commercially applicable cytostatic agent recommended for melanoma therapy.;1 cl, 2 tbl, 4 dwg