METHOD OF TREATING OPERABLE ADENOCARCINOMA OF DUODENUM

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely to oncology, and can be used for treating operable duodenum adenocarcinoma. Method involves surgical removal of the tumor and chemotherapy. No earlier than two days before surgical removal, neoadjuvant chemotherapy is performed by intra-arterial bolus administration of 50 mg/m² abraxane in its suspension in no more than 3 ml of lipidol through a catheter inserted into a gastroduodenal artery. Catheter is then reinserted into celiac and 5-fluorouracil is introduced in amount of 1,000 mg/m² for one hour and additionally 50 mg/m² oxaliplatin for 30 minutes. Thereafter, no later than 4 weeks after surgical removal of the tumor, adjuvant chemotherapy with capecitabine is administered orally daily at 2,500 mg/m² per day in 2 doses in the morning and in the evening for no more than 14 days, while taking capecitabine once a month for not more than 4 months.;EFFECT: method provides reduced total toxic effect on patient's body due to regional administration of chemopreparations.;1 cl, 1 ex