STRAIN OF A RECOMBINANT PSEUDO ADENOVIRAL PARTICLE BASED ON HUMAN ADENOVIRUS GENOME OF SEROTYPE 5 Ad5-tetOFF-E3-HA125 SEROTYPE, CARRYING HAEMAGGLUTININ CONSENSUS GENE OF INFLUENZA VIRUS SUBTYPES H1, H2, H5 FOR PRODUCING INFLUENZA IMMUNOGENIC PREPARATIONS, METHOD FOR PRODUCING GENE

摘要

FIELD: biotechnology; medicine.;SUBSTANCE: invention refers to biotechnology, virology, medicine. Described is a strain of a recombinant pseudo adenoviral particle based on human adenovirus genome 5 of serotype Ad5-tetOFF-E3-HA125 for producing anti-influenza immunogenic preparations, carrying a consensus gene of haemagglutinin virus of influenza A virus subtypes H1, H2, H5 enriched with B and T-cell epitopes of influenza virus with nucleotide sequence SEQ ID NO: 2, wherein the influenza A haemagglutinin consensus sequence gene codes the amino acid sequence SEQ ID NO: 1. Method for preparing a haemagglutinin consensus sequence with the nucleotide sequence SEQ ID NO: 2. Also described is an immunogenic preparation containing a strain of a recombinant pseudo adenoviral particle based on human adenovirus genome 5 of a serotype according to claim 1. for preventing influenza A, caused by subtypes H1, H2 and H5, containing per dose: recombinant pseudo adenoviral particle Ad5-tetOFF-E3-HA125 - 10⁷-10⁹ actuation components. and a pharmaceutically acceptable buffer solution - up to 0.5 ml.;EFFECT: invention extends the range of agents for preventing influenza A.;3 cl, 8 dwg, 1 tbl, 7 ex