COMPLEX PHARMACEUTICAL COMPOSITION COMPRISING AMLODIPINE, LOSARTAN AND CHLORTHALIDONE

摘要

FIELD: medicine; pharmaceuticals.;SUBSTANCE: present invention relates to a combined pharmaceutical composition for preventing or treating cardiovascular diseases. Composition contains a first mixture containing amlodipine, chlorothalidone and a pharmaceutically acceptable additive which is lactose hydrate and microcrystalline cellulose at a weight ratio of 1:0.5 to 1:2, and a second mixture containing losartan and an additive. First and second mixtures are contained in physically separated forms. Combination composition according to the invention is preferably a two-layer tablet. Also described is a method of producing a combined composition and a two-layer tablet.;EFFECT: combined composition of the invention is characterized by high degrees of solubility of amlodipine, losartan and chlorthalidone and improved stability during storage.;8 cl, 13 dwg, 12 tbl, 6 ex