Fc FUSION HIGH AFFINITY IgE RECEPTOR α-CHAIN

摘要

FIELD: biotechnology.;SUBSTANCE: invention relates to biotechnology, specifically to immunology, and can be used in medicine for preventing and treating IgE mediated diseases. Disclosed is an Fc-fusion protein comprising an alpha chain of a high-affinity IgE receptor, a linker, an Fc region of IgG1, and the amino acid sequence presented in SEQ ID NO: 3, or an amino acid sequence comprising a lysine (K) deletion at the C-terminal of the amino acid sequence presented in SEQ ID NO: 3.;EFFECT: invention enables to obtain high-affinity IgE receptor fused to Fc α-chain stable at low pH.;4 cl, 3 dwg, 2 ex