;(I);and crystalline forms thereof (I) and (II), wherein said crystalline forms have characteristic peaks expressed in degrees 2θ(±0.2 2θ), at 21.563, 21.156, 23.295, 21.955 and 20.838 on an X-ray powder diffraction pattern obtained with radiation of Cu-Kα for form (I) and at 3.274, 21.481, 23.887 for form (II).;EFFECT: said rotigotine behenate is characterized by the ability to maintain its effective concentration in plasma for a long period of time, has high bioavailability and can provide the effect of prolonged, effective and stable release.;19 cl, 10 dwg, 6 tbl, 9 ex"/> ROTIGOTINE BEHENATE, METHOD FOR PRODUCTION AND USE THEREOF
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ROTIGOTINE BEHENATE, METHOD FOR PRODUCTION AND USE THEREOF

机译:山HEN酸罗替考汀,其生产方法和用途

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to rotigotine behenate represented by formula (I):; ;(I);and crystalline forms thereof (I) and (II), wherein said crystalline forms have characteristic peaks expressed in degrees 2θ(±0.2 2θ), at 21.563, 21.156, 23.295, 21.955 and 20.838 on an X-ray powder diffraction pattern obtained with radiation of Cu-Kα for form (I) and at 3.274, 21.481, 23.887 for form (II).;EFFECT: said rotigotine behenate is characterized by the ability to maintain its effective concentration in plasma for a long period of time, has high bioavailability and can provide the effect of prolonged, effective and stable release.;19 cl, 10 dwg, 6 tbl, 9 ex
机译:发明领域本发明涉及由式(I)表示的罗替戈汀山hen酸酯: ;(I);及其晶形(I)和(II),其中所述晶形在X射线粉末上具有在21.563、21.156、23.295、21.955和20.838处以2θ(±0.22θ)度表示的特征峰。 (I)形式的Cu-Kα辐射和(II)形式的3.274、21.481、23.887辐射获得的衍射图;效果:所述罗替戈汀山hen酸酯的特征是能够在血浆中长期保持其有效浓度时间,高生物利用度并可以提供延长,有效和稳定的释放效果。; 19 cl,10 dwg,6 tbl,9 ex

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