GENE-THERAPY DNA-VECTOR BASED ON GENE-THERAPY DNA-VECTOR VTVAF17, CARRYING TARGET GENE SELECTED FROM GROUP OF GENES IL11, LIF, DICER, HOXA10, WT1, TO INCREASE EXPRESSION LEVEL OF THESE TARGET GENES, METHOD FOR PRODUCTION AND USE THEREOF, STRAIN ESCHERICHIA COLI SCS110-AF/VTVAF17-IL11, OR ESCHERICHIA COLI SCS110-AF/VTVAF17-LIF, OR ESCHERICHIA COLI SCS110-AF/VTVAF17-DICER, OR ESCHERICHIA COLI SCS110-AF/VTVAF17-HOXA10, OR ESCHERICHIA COLI SCS110-AF/VTVAF17-WT1, CARRYING GENE-THERAPEUTIC DNA VECTOR, METHOD FOR PRODUCTION THEREOF, METHOD FOR INDUSTRIAL PRODUCTION OF GENE-THERAPEUTIC DNA VECTOR

摘要

FIELD: biotechnology.;SUBSTANCE: invention relates to genetic engineering and can be used in biotechnology for developing gene therapy preparations. Gene-therapy DNA vector based on the VTvaf17 gene-therapy vector DNA is created, carrying a target gene selected from a group of IL11, LIF, DICER, HOXA10, WT1 genes to increase the level of expression of this target gene in the human and animal body, wherein the gene-therapy DNA vector VTvaf17-IL11, or VTvaf17-LIF, or VTvaf17-DICER, or VTvaf17-HOXA10, or VTvaf17-WT1 has a nucleotide sequence SEQ ID No. 1, or SEQ ID No. 2, or SEQ ID No. 3, or SEQ ID No. 4, or SEQ ID No. 5 respectively.;EFFECT: invention provides the possibility of its safe application for genetic therapy of humans and animals.;16 cl, 16 dwg, 22 ex