TRANSGENIC MICE EXPRESSING HUMAN LIPOPROTEIN (A) WITH DISCONNECTED VITAMIN C GENE, AND THEIR USE AS A DISEASE TREATMENT MODEL

摘要

FIELD: biochemistry.;SUBSTANCE: invention relates to use of a mouse comprising a non-functional GULO gene (GULO-/-), a human apoB-100 gene and a human apoB(a) gene expressing a human apoB-100 gene (apoB-100+) and human apo(a) gene (apo(a)+), as well as non-producing vitamin C and human producing Lp(a), to determine the possibility of combining human Lp(a) related disease treatment.;EFFECT: invention enables effective testing of pharmaceutical compounds for efficacy and applicability in preventing and/or treating diseases associated with human Lp(a).;8 cl, 8 dwg, 7 tbl