METHOD FOR PREDICTING THE EFFECTIVENESS OF ADJUVANT INTERFERON THERAPY OF SKIN MELANOMA

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely to oncology, and can be used for prediction of efficiency of adjuvant interferon therapy of skin melanoma. In homogenates of tumor tissue and adjacent visually unchanged tissue – peritumoral zone, obtained for no more than 1 hour after operation, quantitative content of cytokines is determined by EIA method: IFN-γ in tumor and peritumoral region, IL-1β and IL-2 in peritumoral region. Their specific levels are calculated, by the formula the prognostic coefficient K is determined: ; ,;where exp – exponent; z – coefficient of linear regression = 4.81-0.16*X1+2.3*X2-0.75*X3-0.34*X4, XI – IL-1β of the peritumoral zone; X2 – IFN-γ of tumors; X3 – IFN-γ of peritumoral zone; X4 – IL-2 peritumoral area pg/ml/g of protein. If K is more than 0.4, a favorable response to adjuvant interferon therapy is predicted.;EFFECT: method provides higher accuracy and information value of prediction of effectiveness of adjuvant interferon therapy of skin melanoma by determining indicators, predicting the effectiveness of interferon therapy in skin melanoma patients: IL-1β, IFN-γ, IL-2, and calculating an individual prognosis by a prognostic coefficient K, calculated using a logistic regression equation.;1 cl, 2 dwg, 1 tbl, 2 ex