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CHIMERIC ANTIGENIC RECEPTOR AND T-CELLS, IN WHICH THE CHIMERIC ANTIGEN RECEPTOR IS EXPRESSED
CHIMERIC ANTIGENIC RECEPTOR AND T-CELLS, IN WHICH THE CHIMERIC ANTIGEN RECEPTOR IS EXPRESSED
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机译：表达嵌合抗原受体的嵌合抗原受体和T细胞
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摘要
FIELD: biotechnology.;SUBSTANCE: invention represents a chimeric antigen receptor for treating cancer expressing IL13Rα2 containing an antigen-binding domain; hinge region; transmembrane domain; costimulatory domain and a cytoplasmic signaling domain, wherein the antigen-binding domain binds to IL13Rα2 and wherein in the antigen-binding domain of 11th, 64th, 67th and 107th amino acid sequence positions denoted SEQ ID NO: 1, substituted with lysine (K), aspartic acid (D), aspartic acid (D) and lysine (K) respectively. Invention also relates to a CAR-T-cell expressing said chimeric antigen receptor.;EFFECT: invention enables treating cancer with high degree of effectiveness.;8 cl, 16 dwg, 5 ex
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机译：发明领域本发明涉及用于治疗表达含有抗原结合域的IL13Rα2的癌症的嵌合抗原受体。铰链区跨膜结构域共刺激结构域和胞质信号传导结构域，其中抗原结合结构域与IL13Rα2结合，并且其中在抗原结合结构域的第11、64、67和107个氨基酸序列位置表示为SEQ ID NO：1，被赖氨酸（K）取代，天冬氨酸（D），天冬氨酸（D）和赖氨酸（K）。本发明还涉及表达所述嵌合抗原受体的CAR-T细胞。效果：本发明能够高度有效地治疗癌症。8 cl，16 dwg，5 ex
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